Congratulations to Dr. Martin Safo

Congratulations to Dr. Martin Safo

September 11, 2017

Congratulations to Dr. Martin Safo, who received $30,000 from Bioverativ for “Determining the Crystal Structure of Variant of Modified Hemoglobin.” 

Srinivas Sistla joined ISB3D

Srinivas Sistla joined ISB3D

September 11, 2017

Srinivas Sistla joined ISB3D effective September 1, 2017 as laboratory manager for Umesh Desai’s lab. Dr. Sistla is a former product manager (label-free interaction analysis) for GE Healthcare. 

Dr. Martin Safo and His Research Team Published in Molecular Pharmaceutics

Dr. Martin Safo and His Research Team Published in Molecular Pharmaceutics

September 11, 2017

Design, Synthesis, and Biological Evaluation of Ester and Ether Derivatives of Antisickling Agent 5-HMF for the Treatment of Sickle Cell Disease.

Xu GG, Pagare PP, Ghatge MS, Safo RP, Gazi A, Chen Q, David T, Alabbas AB, Musayev FN, Venitz J, Zhang Y, Safo MK, Abdulmalik O.

Dr. Darrell Peterson Published in Scientific Reports

Dr. Darrell Peterson Published in Scientific Reports

September 11, 2017

Dissecting the structural basis of MEIG1 interaction with PACRG.

Li W, Walavalkar NM, Buchwald WA, Teves ME, Zhang L, Liu H, Bilinovich S, Peterson DL, Strauss JF 3rd, Williams DC Jr, Zhang Z.

Daniel Asofah has completed the Medicinal Chemistry graduate program.

Daniel Asofah has completed the Medicinal Chemistry graduate program.

July 13, 2017

Daniel Asofah has completed the Medicinal Chemistry graduate program.  He will remain at the Institute as a postdoctoral researcher.  Congratulations Dr. Asofah.

Brianna Mackie has completed her graduate program in Medicinal Chemistry

Brianna Mackie has completed her graduate program in Medicinal Chemistry

July 12, 2017

Congratulations to Brianna Mackie who graduated and obtained her doctorate degree in Medicinal Chemistry.  Dr. Mackie is now a Project Specialist for a Clinical Trial Company in Raleigh, North Carolina.

Dr. Rong Huang accepts faculty position at Purdue University

Dr. Rong Huang accepts faculty position at Purdue University

July 11, 2017

Dr. Huang is Associate Professor at Purdue University’s College of Pharmacy in the Department of Medicinal Chemistry and Molecular Pharmacology.  We wish her much success in her endeavors.

Daniel Afosah was named a Future Glycogen leader for the 2017 InterPEG conference.

Daniel Afosah was named a Future Glycogen leader for the 2017 InterPEG conference.

April 13, 2017

Congratulations!

Daniel Afosah, a graduate student in Dr. Umesh Desai’s lab, was named a Future Glycogen leader for the 2017 InterPEG conference.  This annual conference is in association with Dr. Desai’s NIH/NHLBI, Chemistry and Biology of Heparan Sulfate grant.  

Daniel Afosah named the Department of Medicinal Chemistry’s 2017 J. Doyle Smith Award for Outstanding Graduate student.

Daniel Afosah named the Department of Medicinal Chemistry’s 2017 J. Doyle Smith Award for Outstanding Graduate student.

April 12, 2017

Daniel Afosah named the Department of Medicinal Chemistry’s 2017 J. Doyle Smith Award for Outstanding Graduate student.

Congratulations to Dr. Martin Safo on receiving a $600,000 equipment NIH grant.

Congratulations to Dr. Martin Safo on receiving a $600,000 equipment NIH grant.

March 15, 2017

Congratulations to Dr. Martin Safo on receiving a $600,000 equipment NIH grant for an X-ray crystallographic data collection system, project period 03/15/17 – 03/14/18. 

Published in collaboration with Dr. Stefan Oscarson and his research group from the University College of Dublin

Published in collaboration with Dr. Stefan Oscarson and his research group from the University College of Dublin

February 20, 2017

A Hexasaccharide Containing Rare 2-O-Sulfate-Glucuronic Acid Residues Selectively Activates Heparin Cofactor II”.  Sankarayanan, NV, Strebel T.R., Boothello, R.S., Sheerin, K., Raghuraman, A., Sallas, F. Mosier, P.D., Watermeyer, N.D. Oscarson, S Desai, U.R., 2017 February 20; 56(9): 2312-2317, Angew. Chem. Int. Ed Engl.

In collaboration with the Dr. Erin Wall from the Laboratory of Molecular Biology

In collaboration with the Dr. Erin Wall from the Laboratory of Molecular Biology

February 10, 2017

In collaboration with the Dr. Erin Wall from the Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, Bethesda, MD and research colleague, Gail Christie, Ph.D. from VCU Department of Microbiology and Immunology.

Structural Modeling and Functional Analysis of the Essential Ribosomal Processing Protease Prp from Staphylococcus Aureus”.  Wall, E. A., Johnson, A. L., Peterson, D.L., Christie, G.E., 2017 February 10, Molecular Microbiology

Paper published in collaboration with Bhaumik Patel

Paper published in collaboration with Bhaumik Patel

February 9, 2017

 

This paper was published in collaboration with Bhaumik Patel, MD and his research group from the Hunter Holmes McGuire Hospital and VCU Massey Cancer Center.

A molecular dynamics-based algorithm for evaluating the glycosaminoglycan mimicking potential of synthetic, homogenous, sulfated small molecules”.  Nagarajan, B., Sankaranarayanan, N.V., Patel, B.B., Desai, U.R., 2017 February 9, PLoS One

Dr. Desai’s lab published in Journal of Medicinal Chemistry

Dr. Desai’s lab published in Journal of Medicinal Chemistry

January 26, 2017

Potent, Selective, Allosteric Inhibition of Human Plasmin by Sulfated Non-Saccharide Glycosaminoglycan Mimetics”.  Afosah, D.K., Al-Horani, R.A., Sankaranarayanan, N.V., Desai, U.R., 2017 January 26; 60(2): 641-657, J. Med. Chem.

In collaboration with John B. Mangrum from the Food and Drug Administration

In collaboration with John B. Mangrum from the Food and Drug Administration

January 1, 2017

In collaboration with John B. Mangrum from the Food and Drug Administration, “Comparative analysis of INLIGHT™-labeled enzymatically depolymerized heparin by reverse-phase chromatography and high-performance mass spectrometry”. Mangrum JB, Mehta AY, Alabbas AB, Desai UR, Hawkridge AM., Anal Bioanal Chem. 2017 Jan; 409(2):499-509

Drs. Peterson and Ellis labs published in Organic and Biomolecular Chemistry

Drs. Peterson and Ellis labs published in Organic and Biomolecular Chemistry

May 18, 2016

Design, Synthesis, and in vitro evaluation of a fluorescently labeled irreversible inhibitor of the catalytic subunit of cAMP-dependent protein kinase (PKACα)”.  Coover, R.A., Luzi, N.M., Korwar, S. Casile, M.E., Lyons, C.E. Peterson, D.L., Ellis, K.C., 2016 May 18; 14(20): 4576-81, Org. Biomol. Chem

Paper published in collaboration with Bhaumik Patel

Paper published in collaboration with Bhaumik Patel

December 20, 2016

 This paper was published in collaboration with Bhaumik Patel, MD and his research group from the Hunter Holmes McGuire Hospital and VCU Massey Cancer Center

"Heparan Sulfate hexasaccharide selectively inhibits cancer stem cells self-renewal by activating p38 MAP kinase".  Patel, N.J., Sharon, C., Baranwal, S., Boothello, R.S., Desai, U.R., Patel, B.B., 2016 December 20; 7(51): 84608-84622, Oncotarget

New Graduate Student Claudio Catalano

New Graduate Student Claudio Catalano

November 2, 2016

Claudio Catalano received his BS/MS in Pharmaceutical Chemistry and Technology (he is also a pharmacist) from the University of Messina in Italy and was a rotation/exchange student from Messina at VCU in 2013. Claudio's Ph.D. project in Medicinal Chemistry will be jointly mentored by Glen Kellogg and Youzhong Guo and will involve crystallography and modeling of membrane-bound proteins.

Founding Director Visits Institute

Founding Director Visits Institute

November 2, 2016

Dr. Donald J. Abraham visited ISB3D for 2 days and met with former colleagues and presented an inspiring seminar, titled "Drug Discovery in Academia". He was also presented with an award acknowledging him as the founder of the Institute for Structural Biology and Drug Discovery.

New Graduate Student Heather Pendergrass

New Graduate Student Heather Pendergrass

November 2, 2016

Heather Pendergrass completed her Bachelor's degree at Virginia Tech, with a double major in biochemistry and chemistry; her background is in antimicrobials and autoimmune disorder therapies, and she is working to receive her Ph.D. in Medicinal Chemistry with the May Lab.

Desai's lab published work in the American Journal of Respiratory Cell and Molecular Biology

Desai's lab published work in the American Journal of Respiratory Cell and Molecular Biology

October 7, 2016

In collaboration with the Voynow laboratory at the VCU, School of Medicine, the work titled, "2-0, 3-0 Desulfated Heparin Blocks HMGB1 Release by Inhibition of p300 Acetyltransferase Activity" was published.  The contributing members from Desai's laboratory were Daniel Afosah, Rio Boothello and Nehru Viji Sankaranarayanan.  

Desai's lab published in Scientific Reports,

Desai's lab published in Scientific Reports, "Broad Spectrum Anti-Influenza Agents by Inhibiting Self-Association of Matrix Protein 1"

October 7, 2016

Results were published in collaboration with the Xie laboratory of the US Food and Drug Administration on assessing the potential for targeting a novel protein M1 of influenza virus A for a new line of anti-viral agents.  Institute members that contributed effort were Philip Mosier, Bashayer Althufairi, Faik Musayev, Martin Safo and Umesh Desai.  The link to the publication is here.

Dr. Martin Safo published a paper in Br. J. Haem.

Dr. Martin Safo published a paper in Br. J. Haem.

October 1, 2016

 In collaboration with Dr. O. Abdulmalik of the Division of Hematology, The Children's Hospital of Philadelphia, Philadelphia, PA, and Dr. G.J., Kara from the Department of Medicine, Division of Hematology-Oncology and the Heart, Lung, Blood and Vascular Medicine Institute, University of Pittsburgh School of Medicine

New Developments in anti-sickling agents: can drugs directly prevent the polymerization of sickle haemoglobin in vivo?”  British Journal Haematology