Dr. Umesh R. Desai

Polymeric fluorescent heparin as one-step FRET substrate of human heparanase.

Co-Authors: Sistla JC, Morla S, Alabbas AB, Kalathur RC, Sharon C, Patel BB.

Carbohydrate Polymers. 2019 Feb 1.


Structural basis, stoichiometry, and thermodynamics of binding of the chemokines KC and MIP2 to the glycosaminoglycan heparin.

Journal of Biological Chemistry. 2018 Sep 26.

Co-authors:  Sepuru KM, Nagarajan B, Rajarathnam K.


Structural basis, stoichiometry, and thermodynamics of binding of the chemokines KC and MIP2 to the glycosaminoglycan heparin.

Journal of Biological Chemistry. 2018 Sep 26.

Co-authors:  Sepuru KM, Nagarajan B, Rajarathnam K.


Lysines and Arginines play non-redundant roles in mediating chemokine-glycosaminoglycan interactions.

Scientific Reports. 2018 Aug 16;8

Co-authors:  Joseph PRB, Sawant KV, Iwahara J, Garofalo RP, Rajarathnam K.


Inhibition of Herpes Simplex Virus-1 Entry into Human Cells by Nonsaccharide Glycosaminoglycan Mimetics.

ACS Medicinal Chemistry Letters. 2018 Jul 16;9(8):797-802.

Co-authors:  Gangji RN, Sankaranarayanan NV, Elste J, Al-Horani RA, Afosah DK, Joshi R, Tiwari V


Molecular principles for heparin oligosaccharide-based inhibition of neutrophil elastase in cystic fibrosis.

J Biol Chem. 2018 Jun 14.

Co-authors:  Kummarapurugu AB, Afosah DK, Sankaranarayanan NV, Gangji RN, Zheng S, Kennedy TP, Rubin BK, Voynow JA


A small group of sulfated benzofurans induces steady-state submaximal inhibition of thrombin.

Bioorganic & Medicinal Chemistry Letters. 2018 Apr 1;28(6):1101-1105

Co-authors:  Afosah DK, Verespy S 3rd, Al-Horani RA, Boothello RS, Karuturi R,


Novel heparin mimetics reveal cooperativity between exosite 2 and sodium-binding site of thrombin.

Thrombosis Research Journal, 2018 Mar 17;165:61-67

Co-author:  Abdel Aziz MH


anexVis: Visual analytics framework for analysis of RNA expression.

Bioformatics, 2018 Mar 1. doi: 10.1093

Co-authors:  Tran DT, Zhang T, Stutsman R, Might M, Kuberan B.


So you think computational approaches to understanding glycosaminoglycan-protein interactions are too dry and too rigid? Think again!

Current Opinion in Structural Biology, 2018 Jan 9;50:91-100

Co-authors:  Sankaranarayanan NV, Nagarajan B.


A synthetic heparin mimetic that allosterically inhibits factor XIa and reduces thrombosis in vivo without enhanced risk of bleeding.

J Thromb Haemost. 2019 Dec;17(12):2110-2122.

Co-authors: Al-Horani RA, Abdelfadiel EI, Afosah DK, Morla S, Sistla JC, Mohammed B, Martin EJ, Sakagami M, Brophy DF, Desai UR.


Dr. Darrell Peterson

Fusogenic properties of the Ectodomain of HCV E2 envelope protein.

Biochimica et Biophysica Acta (BBA) 2018 Mar; 1860(3):728-736

Co-authors:  Rodríguez-Rodríguez M, Tello D, Gómez-Gutiérrez J, Gavilanes F, Yélamos B.


Dr. Darrell Peterson, Dr. Keith Ellis

Kinetics and inhibition studies of the L205R mutant of cAMP-dependent protein kinase involved in Cushing's syndrome.

FEBS Open Bio. 2018 Mar 11;8(4):606-613

Co-authors:  Luzi NM and Lyons CE


Dr. Keith Ellis

An intestinal stem cell niche in Apc mutated neoplasia targetable by CtBP inhibition.

Co-Authors?  Chawla AT, Cororaton AD, Idowu MO, Damle PK, Szomju B, Patel BB, Grossman

SR.Oncotarget. 2018 Aug 21.


Dr. Martin Safo

Rational modification of vanillin derivatives to stereospecifically destabilize sickle hemoglobin polymer formation.

Acta Crystallographica Section D Structural Biology. 2018 Oct 1;74(Pt 10):956-964.

Co-authors:  Deshpande TM, Pagare PP, Ghatge MS, Chen Q, Musayev FN, Venitz J, Zhang Y, Abdulmalik O


Design, Synthesis, and Biological Evaluation of Allosteric Effectors That Enhance CO Release from Carboxyhemoglobin.

ACS Medicinal Chemistry Letters. 2018 May 11;9(7):714-718.

Co-authors: Goldstein SR, Liu C, Nakagawa A, Zapol WM, Winkler JD.


Rational design of pyridyl derivatives of vanillin for the treatment of sickle cell disease.

Bioorganic and Medicinal Chemistry. 2018 May 15;26 (9):2530-2538.

Co-authors: Pagare PP, Ghatge MS, Musayev FN, Deshpande TM, Chen Q, Braxton C, Kim S, Venitz J, Zhang Y, Abdulmalik O.


A Triazole Disulfide Compound Increases the Affinity of Hemoglobin for Oxygen and Reduces the Sickling of Human Sickle Cells.

Molecular Pharmaceutics, 2018 Apr 18. doi: 10.1021

Co-authors:  Nakagawa A, Ferrari M, Schleifer G, Cooper MK, Liu C, Yu B, Berra L, Klings ES, Safo RS, Chen Q, Musayev FN, Abdulmalik O, Bloch DB, Zapol WM.


Dr. Glen Kellogg and Dr. Yan Zhang

Exploring the binding mechanisms of diaminopimelic acid analogs to meso-diaminopimelate dehydrogenase by molecular modeling.

J Mol Graph Model. 2018 Aug;83:100-111.

Co-authors:  Wang H, Xu P


Dr. Jiong Li

Low Doses of Decitabine Improve the Chemotherapy Efficacy against Basal-like Bladder Cancer by Targeting Cancer Stem Cells. 
Co-Authors: W. Mingquin, L. Sheng, M. Cheng, H. Zhang, Y. Liang, F. Zhu, Z. Liu, Y. Zhang, X. Zhang, Q. Gao, D. Chen, Y. Li. 
Onocogene. March 27, 2019 


Dr. Youzhong Guo

Structure and activity of lipid bilayer within a membrane-protein transporter

Proceedings of the National Academy of Sciences of the United States of America (PNAS)

Co-authors: Weihua Qiu, Ziao Fu, Guoyan G. Xu, Robert A. Grassucci, Yan Zhang, Joachim Frank, Wayne A. Hendrickson


Dr. Faik Musayev

Nitrosative stress sensing in Porphyromonas gingivalis: structure of and heme binding by the transcriptional regulator HcpR.

Acta Crystallographica Section D: Structural Biology. 2019 Apr 1;75(Pt 4):437-450

Co-authors: Belvin BR, Burgner J, Scarsdale JN, Escalante CR, Lewis JP.