Fall 2016 Archive
Dr. Fengtian Xue, Assistant Professor
University of Maryland, School of Pharmacy
"Small Molecule Inhibitors of the BCL6 BTB Domain for the Treatment of Diffuse Large B-cell Lymphoma"
Dr. Shirley Taylor, Associate Professor
Virginia Commonwealth University, Department of Microbiolgy/Immunology
"Mitochondrial Epigenetics and Transcription Control"
Dr. Donald J. Abraham, Professor Emeritus
Virginia Commonwealth University, Professor Emeritus Dept. of Medicinal Chemistry
"Drug Discovery in Academia"
Dr. Lawrence Povirk, Professor
Virginia Commonwealth University - Dept. of Pharmacology and Toxicology
"Resolution of Oxidative Damage at DNA Ends in Double-Strand Break Repair"
Dr. Songon An, Assistant Professor
University of Maryland, Baltimore County
"A Regulatory Enzyme Complex for Glucose Metabolism in Living Cells: The Glucose"
Dr. David S. Lawrence, Fred Eshelman Distinguished Professor and Chair
University of North Carolina at Chapel Hill, School of Pharmacy
"Illuminating the Path for Cell Signaling and Drug Delivery"
Dr. Xiang-Yang Wang (Shawn), Mary Anderson Harrison Distinguished Professor
Virginia Commonwealth University, Dept. of Human and Molecular Genetics
"Innate Pattern Recognition Receptors as Potential Therapeutic Targets in Cancer and Inflammatory Diseases"
Drs. Peterson and Ellis labs published in Organic and Biomolecular Chemistry
May 18, 2016
“Design, Synthesis, and in vitro evaluation of a fluorescently labeled irreversible inhibitor of the catalytic subunit of cAMP-dependent protein kinase (PKACα)”. Coover, R.A., Luzi, N.M., Korwar, S. Casile, M.E., Lyons, C.E. Peterson, D.L., Ellis, K.C., 2016 May 18; 14(20): 4576-81, Org. Biomol. Chem
Dr. Martin Safo published a paper in Br. J. Haem.
October 1, 2016
In collaboration with Dr. O. Abdulmalik of the Division of Hematology, The Children's Hospital of Philadelphia, Philadelphia, PA, and Dr. G.J., Kara from the Department of Medicine, Division of Hematology-Oncology and the Heart, Lung, Blood and Vascular Medicine Institute, University of Pittsburgh School of Medicine
“New Developments in anti-sickling agents: can drugs directly prevent the polymerization of sickle haemoglobin in vivo?” British Journal Haematology
Paper published in collaboration with Bhaumik Patel
December 20, 2016
This paper was published in collaboration with Bhaumik Patel, MD and his research group from the Hunter Holmes McGuire Hospital and VCU Massey Cancer Center
"Heparan Sulfate hexasaccharide selectively inhibits cancer stem cells self-renewal by activating p38 MAP kinase". Patel, N.J., Sharon, C., Baranwal, S., Boothello, R.S., Desai, U.R., Patel, B.B., 2016 December 20; 7(51): 84608-84622, Oncotarget
Desai's lab published in Scientific Reports, "Broad Spectrum Anti-Influenza Agents by Inhibiting Self-Association of Matrix Protein 1"
October 7, 2016
Results were published in collaboration with the Xie laboratory of the US Food and Drug Administration on assessing the potential for targeting a novel protein M1 of influenza virus A for a new line of anti-viral agents. Institute members that contributed effort were Philip Mosier, Bashayer Althufairi, Faik Musayev, Martin Safo and Umesh Desai. The link to the publication is here.
Desai's lab published work in the American Journal of Respiratory Cell and Molecular Biology
October 7, 2016
In collaboration with the Voynow laboratory at the VCU, School of Medicine, the work titled, "2-0, 3-0 Desulfated Heparin Blocks HMGB1 Release by Inhibition of p300 Acetyltransferase Activity" was published. The contributing members from Desai's laboratory were Daniel Afosah, Rio Boothello and Nehru Viji Sankaranarayanan.
New Graduate Student Heather Pendergrass
November 2, 2016
Heather Pendergrass completed her Bachelor's degree at Virginia Tech, with a double major in biochemistry and chemistry; her background is in antimicrobials and autoimmune disorder therapies, and she is working to receive her Ph.D. in Medicinal Chemistry with the May Lab.
New Graduate Student Claudio Catalano
November 2, 2016
Claudio Catalano received his BS/MS in Pharmaceutical Chemistry and Technology (he is also a pharmacist) from the University of Messina in Italy and was a rotation/exchange student from Messina at VCU in 2013. Claudio's Ph.D. project in Medicinal Chemistry will be jointly mentored by Glen Kellogg and Youzhong Guo and will involve crystallography and modeling of membrane-bound proteins.
Founding Director Visits Institute
November 2, 2016
Dr. Donald J. Abraham visited ISB3D for 2 days and met with former colleagues and presented an inspiring seminar, titled "Drug Discovery in Academia". He was also presented with an award acknowledging him as the founder of the Institute for Structural Biology and Drug Discovery.