Fall 2016 Archive

SEP 7

Dr. Fengtian Xue, Assistant Professor

University of Maryland, School of Pharmacy

"Small Molecule Inhibitors of the BCL6 BTB Domain for the Treatment of Diffuse Large B-cell Lymphoma"

SEP 21

Dr. Shirley Taylor, Associate Professor

Virginia Commonwealth University, Department of Microbiolgy/Immunology

"Mitochondrial Epigenetics and Transcription Control"

OCT 5

Dr. Donald J. Abraham, Professor Emeritus

Virginia Commonwealth University, Professor Emeritus Dept. of Medicinal Chemistry

"Drug Discovery in Academia"

OCT 19

Dr. Lawrence Povirk, Professor

Virginia Commonwealth University - Dept. of Pharmacology and Toxicology

"Resolution of Oxidative Damage at DNA Ends in Double-Strand Break Repair"

NOV 2

Dr. Songon An, Assistant Professor

University of Maryland, Baltimore County

"A Regulatory Enzyme Complex for Glucose Metabolism in Living Cells: The Glucose"

NOV 16

Dr. David S. Lawrence, Fred Eshelman Distinguished Professor and Chair

University of North Carolina at Chapel Hill, School of Pharmacy

"Illuminating the Path for Cell Signaling and Drug Delivery"

NOV 30

Dr. Xiang-Yang Wang (Shawn), Mary Anderson Harrison Distinguished Professor

Virginia Commonwealth University, Dept. of Human and Molecular Genetics

"Innate Pattern Recognition Receptors as Potential Therapeutic Targets in Cancer and Inflammatory Diseases"

Drs. Peterson and Ellis labs published in Organic and Biomolecular Chemistry

Drs. Peterson and Ellis labs published in Organic and Biomolecular Chemistry

May 18, 2016

Design, Synthesis, and in vitro evaluation of a fluorescently labeled irreversible inhibitor of the catalytic subunit of cAMP-dependent protein kinase (PKACα)”.  Coover, R.A., Luzi, N.M., Korwar, S. Casile, M.E., Lyons, C.E. Peterson, D.L., Ellis, K.C., 2016 May 18; 14(20): 4576-81, Org. Biomol. Chem

Dr. Martin Safo published a paper in Br. J. Haem.

Dr. Martin Safo published a paper in Br. J. Haem.

October 1, 2016

 In collaboration with Dr. O. Abdulmalik of the Division of Hematology, The Children's Hospital of Philadelphia, Philadelphia, PA, and Dr. G.J., Kara from the Department of Medicine, Division of Hematology-Oncology and the Heart, Lung, Blood and Vascular Medicine Institute, University of Pittsburgh School of Medicine

New Developments in anti-sickling agents: can drugs directly prevent the polymerization of sickle haemoglobin in vivo?”  British Journal Haematology

Paper published in collaboration with Bhaumik Patel

Paper published in collaboration with Bhaumik Patel

December 20, 2016

 This paper was published in collaboration with Bhaumik Patel, MD and his research group from the Hunter Holmes McGuire Hospital and VCU Massey Cancer Center

"Heparan Sulfate hexasaccharide selectively inhibits cancer stem cells self-renewal by activating p38 MAP kinase".  Patel, N.J., Sharon, C., Baranwal, S., Boothello, R.S., Desai, U.R., Patel, B.B., 2016 December 20; 7(51): 84608-84622, Oncotarget

Desai's lab published in Scientific Reports,

Desai's lab published in Scientific Reports, "Broad Spectrum Anti-Influenza Agents by Inhibiting Self-Association of Matrix Protein 1"

October 7, 2016

Results were published in collaboration with the Xie laboratory of the US Food and Drug Administration on assessing the potential for targeting a novel protein M1 of influenza virus A for a new line of anti-viral agents.  Institute members that contributed effort were Philip Mosier, Bashayer Althufairi, Faik Musayev, Martin Safo and Umesh Desai.  The link to the publication is here.

Desai's lab published work in the American Journal of Respiratory Cell and Molecular Biology

Desai's lab published work in the American Journal of Respiratory Cell and Molecular Biology

October 7, 2016

In collaboration with the Voynow laboratory at the VCU, School of Medicine, the work titled, "2-0, 3-0 Desulfated Heparin Blocks HMGB1 Release by Inhibition of p300 Acetyltransferase Activity" was published.  The contributing members from Desai's laboratory were Daniel Afosah, Rio Boothello and Nehru Viji Sankaranarayanan.  

New Graduate Student Heather Pendergrass

New Graduate Student Heather Pendergrass

November 2, 2016

Heather Pendergrass completed her Bachelor's degree at Virginia Tech, with a double major in biochemistry and chemistry; her background is in antimicrobials and autoimmune disorder therapies, and she is working to receive her Ph.D. in Medicinal Chemistry with the May Lab.

New Graduate Student Claudio Catalano

New Graduate Student Claudio Catalano

November 2, 2016

Claudio Catalano received his BS/MS in Pharmaceutical Chemistry and Technology (he is also a pharmacist) from the University of Messina in Italy and was a rotation/exchange student from Messina at VCU in 2013. Claudio's Ph.D. project in Medicinal Chemistry will be jointly mentored by Glen Kellogg and Youzhong Guo and will involve crystallography and modeling of membrane-bound proteins.

Founding Director Visits Institute

Founding Director Visits Institute

November 2, 2016

Dr. Donald J. Abraham visited ISB3D for 2 days and met with former colleagues and presented an inspiring seminar, titled "Drug Discovery in Academia". He was also presented with an award acknowledging him as the founder of the Institute for Structural Biology and Drug Discovery.